Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch. | |
Lv, Ping1,2; Wei, Lixin1; Du, Yuzhi1; Yang, Hongxia1,2; Peng, Min1 | |
2010-04-18 | |
发表期刊 | JOURNAL OF MEDICINAL PLANTS RESEARCH |
ISSN | 1996-0875 |
卷号 | 4期号:8页码:706-709 |
文章类型 | Article |
摘要 | Swertia mussotii Franch. (SM) (Gentianaceae) was a traditional Tibetan folk herb for hepatitis in the Qinghai-Tibet plateau areas. For understanding the hepatoprotection and toxicity characteristics of Swertia mussotii Franch., the whole plant of Swertia mussotii was extracted by water (SME-b) and 75% ethanol (SME-a); then, SME-a was dissolved with water, the supernatant was SME-c, and the sedimentation was SME-d. 17.76% SME-a, 14.48% SME-b, 10.13% SME-c, and 4.35% SME-d were extracted from Swertia mussotii. These four extracts were evaluated with acute toxicity and hepatoprotective effect on CCl(4)-induced acute liver damage in mice. The toxic material mainly reside in SME-c and SME-a. The hepatoprotective materials were in SME-a, SME-c and SME-d, while SME-b had no hepatoprotective activities. So, SME-a and SME-c had both the hepatoprotection and toxicity characteristics; SME-b had no toxicity or the hepatoprotection characteristics; only SME-d was hepatoprotective function without toxicity, which could be a good candidate for new drug healing the live disorder.; Swertia mussotii Franch. (SM) (Gentianaceae) was a traditional Tibetan folk herb for hepatitis in the Qinghai-Tibet plateau areas. For understanding the hepatoprotection and toxicity characteristics of Swertia mussotii Franch., the whole plant of Swertia mussotii was extracted by water (SME-b) and 75% ethanol (SME-a); then, SME-a was dissolved with water, the supernatant was SME-c, and the sedimentation was SME-d. 17.76% SME-a, 14.48% SME-b, 10.13% SME-c, and 4.35% SME-d were extracted from Swertia mussotii. These four extracts were evaluated with acute toxicity and hepatoprotective effect on CCl(4)-induced acute liver damage in mice. The toxic material mainly reside in SME-c and SME-a. The hepatoprotective materials were in SME-a, SME-c and SME-d, while SME-b had no hepatoprotective activities. So, SME-a and SME-c had both the hepatoprotection and toxicity characteristics; SME-b had no toxicity or the hepatoprotection characteristics; only SME-d was hepatoprotective function without toxicity, which could be a good candidate for new drug healing the live disorder. |
关键词 | Swertia Mussotii Franch. Gentianaceae Tibetan Herb Extracts Hepatoprotective Activity Toxicity |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Pharmacology & Pharmacy |
WOS类目 | Chemistry, Medicinal |
WOS记录号 | WOS:000277845700014 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/1720 |
专题 | 中国科学院西北高原生物研究所 |
作者单位 | 1.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Lv, Ping,Wei, Lixin,Du, Yuzhi,et al. Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH,2010,4(8):706-709. |
APA | Lv, Ping,Wei, Lixin,Du, Yuzhi,Yang, Hongxia,&Peng, Min.(2010).Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch..JOURNAL OF MEDICINAL PLANTS RESEARCH,4(8),706-709. |
MLA | Lv, Ping,et al."Hepatoprotective and toxic characteristics of the whole herb of traditional Tibetan folk medicine Swertia mussotii Franch.".JOURNAL OF MEDICINAL PLANTS RESEARCH 4.8(2010):706-709. |
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