The first discovery of Tc1 transposons in yeast

NWIPB OpenIR

	The first discovery of Tc1 transposons in yeast
	Chang, Jia; Duan, Guangyou; Li, Wenjing; Yau, Tung On; Liu, Chang; Cui, Jianlin; Xue, Huaijun; Bu, Wenjun; Hu, Yanping; Gao, Shan
	2023
发表期刊	FRONTIERS IN MICROBIOLOGY
卷号	14
摘要	BackgroundIdentification of transposons without close homologs is still a difficult task. IS630/Tc1/mariner transposons, classified into a superfamily, are probably the most widespread DNA transposons in nature. Tc1/mariner transposons have been discovered in animals, plants, and filamentous fungi, however, not in yeast. ResultsIn the present study, we report the discovery of two intact Tc1 transposons in yeast and filamentous fungi, respectively. The first one, named Tc1-OP1 (DD40E), represents Tc1 transposons in Ogataea parapolymorpha. The second one, named Tc1-MP1 (DD34E), represents Tc1 transposons in the Rhizopodaceae and Mucoraceae families. As a homolog of Tc1-OP1 and Tc1-MP1, IS630-AB1 (DD34E) was discovered as an IS630 transposon in Acinetobacter spp. ConclusionTc1-OP1 is not only the first reported Tc1 transposon in yeast, but also the first reported nonclassical Tc1 transposon. Tc1-OP1 is the largest of IS630/Tc1/mariner transposons reported to date and significantly different from others. Notably, Tc1-OP1 encodes a serine-rich domain and a transposase, extending the current knowledge of Tc1 transposons. The phylogenetic relationships of Tc1-OP1, Tc1-MP1 and IS630-AB1 indicated that these transposons had evolved from a common ancestor. Tc1-OP1, Tc1-MP1 and IS630-AB1 can be used as reference sequences to facilitate the identification of IS630/Tc1/mariner transposons. More Tc1/mariner transposons will be identified in yeast, following our discovery.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61693
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Chang, Jia,Duan, Guangyou,Li, Wenjing,et al. The first discovery of Tc1 transposons in yeast[J]. FRONTIERS IN MICROBIOLOGY,2023,14.
APA	Chang, Jia.,Duan, Guangyou.,Li, Wenjing.,Yau, Tung On.,Liu, Chang.,...&Gao, Shan.(2023).The first discovery of Tc1 transposons in yeast.FRONTIERS IN MICROBIOLOGY,14.
MLA	Chang, Jia,et al."The first discovery of Tc1 transposons in yeast".FRONTIERS IN MICROBIOLOGY 14(2023).