Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS

NWIPB OpenIR

	Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS
	Yue, HL; Wang, LY; Jiang, SR; Banma, CL; Jia, WJ; Tao, YD; Zhao, XH
	2022
发表期刊	FOOD & FUNCTION
卷号	13 期号:3 页码:1659
摘要	Rhodiola crenulata (HK. f. et. Thoms) H. Ohba (RC), mainly distributed in the highly cold region of China, has long been used as a medicine/healthy food for eliminating fatigue and increasing blood circulation. This study aimed to evaluate the inhibitory effects of the RCRS extract on alpha-amylase and alpha-glucosidase (sucrase and maltase) in vitro and in vivo, and tentatively analyze and identify its chemical ingredients using UPLC-Triple-TOF/MS. The Rhodiola crenulata RCRS extract had strong inhibitory activities against alpha-amylase, sucrase and maltase with an IC50 of 0.031 mg mL(-1), 0.142 mg mL(-1) and 0.214 mg mL(-1), respectively. Furthermore, the RCRS extract could significantly decrease the postprandial blood glucose (PBG) level of normal mice in a starch tolerance test, and reduce the PBG levels of diabetic mice in a starch/maltose/sucrose tolerance test. UHPLC-Triple-TOF-MS/MS analysis indicated that hydroxybenzoic acids, hydroxycinnamic acids, alcohol glycosides, flavonols and their derivatives were the main active ingredients in the RCRS extract. The results demonstrate that the RCRS extract of Rhodiola crenulata could be employed as a healthy food or medicine for controlling postprandial blood glucose levels.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61310
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yue, HL,Wang, LY,Jiang, SR,et al. Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS[J]. FOOD & FUNCTION,2022,13(3):1659.
APA	Yue, HL.,Wang, LY.,Jiang, SR.,Banma, CL.,Jia, WJ.,...&Zhao, XH.(2022).Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS.FOOD & FUNCTION,13(3),1659.
MLA	Yue, HL,et al."Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS".FOOD & FUNCTION 13.3(2022):1659.