The major anthocyanin of Lycium ruthenicum Murr. relieves cognitive deficits, oxidative stress, neuroinflammation, and hippocampal metabolome alterations in aging rats

NWIPB OpenIR

	The major anthocyanin of Lycium ruthenicum Murr. relieves cognitive deficits, oxidative stress, neuroinflammation, and hippocampal metabolome alterations in aging rats
	Chen, SS; Hu, N; Wang, HL; Li, GL
	2022
发表期刊	JOURNAL OF FUNCTIONAL FOODS
卷号	94
摘要	Lycium ruthenicum Murr. fruit (LRF) is a functional food that abundant in anthocyanins. In this study, the neuroprotection of the major anthocyanin in LRF, namely petunidin-3,5-O-diglucosides (Pn3G5G), was investigated in D-galactose-induced aging rats. Our results showed that administration of Pn3G5G by oral gavage (100 mg/kg center dot bw) for 7 weeks did not influence the body weight and motor function of rats. More importantly, Pn3G5G could relieve cognitive deficits, mitigate cortical and hippocampal neuron loss, reduce the levels of aging-related markers (AGEs and MDA), increase the ratio of GSH/GSSG, and suppress neuroinflammation in the hippocampus. LC-MS-based metabolomics revealed that Pn3G5G could restore the altered hippocampal metabolic profile. In total, 39 differential metabolites and 47 pathways were involved. Particularly, Pn3G5G corrected amino acid metabolic problems by restoring the levels of L-cystine, L-histidine, L-serine, S-sulfo-L-cysteine, L-asparagine, glutathione (reduced form), L-saccharopine, N-acetyl-L-leucine, 5-oxoproline (pyroglutamic acid), 3-N-methyl-L-histidine and N-methyl-L-glutamate to protect neurons from oxidative stress and inflammatory damage. Besides, Pn3G5G also regulate ABC transporters, protein digestion and absorption, and biosynthesis of cofactors to prevent abnormal energy metabolism of neurons. In conclusion, Pn3G5G likely enhance antioxidant and antiinflammatory defenses, as well as maintain normal function of hippocampus through influencing these metabolic pathways, thereby alleviating cognitive impairment in aging rats.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61166
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Chen, SS,Hu, N,Wang, HL,et al. The major anthocyanin of Lycium ruthenicum Murr. relieves cognitive deficits, oxidative stress, neuroinflammation, and hippocampal metabolome alterations in aging rats[J]. JOURNAL OF FUNCTIONAL FOODS,2022,94.
APA	Chen, SS,Hu, N,Wang, HL,&Li, GL.(2022).The major anthocyanin of Lycium ruthenicum Murr. relieves cognitive deficits, oxidative stress, neuroinflammation, and hippocampal metabolome alterations in aging rats.JOURNAL OF FUNCTIONAL FOODS,94.
MLA	Chen, SS,et al."The major anthocyanin of Lycium ruthenicum Murr. relieves cognitive deficits, oxidative stress, neuroinflammation, and hippocampal metabolome alterations in aging rats".JOURNAL OF FUNCTIONAL FOODS 94(2022).