Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota

NWIPB OpenIR

	Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota
	Fu, Haibo; Zhang, Liangzhi; Fan, Chao; Liu, Chuanfa; Li, Wenjing; Li, Jiye; Zhao, Xinquan; Jia, Shangang; Zhang, Yanming
	2021
发表期刊	FRONTIERS IN MICROBIOLOGY
卷号	12
摘要	Domestication is a key factor of genetic variation; however, the mechanism by which domestication alters gut microbiota is poorly understood. Here, to explore the variation in the structure, function, rapidly evolved genes (REGs), and enzyme profiles of cellulase and hemicellulose in fecal microbiota, we studied the fecal microbiota in wild, half-blood, and domestic yaks based on 16S rDNA sequencing, shotgun-metagenomic sequencing, and the measurement of short-chain-fatty-acids (SCFAs) concentration. Results indicated that wild and half-blood yaks harbored an increased abundance of the phylum Firmicutes and reduced abundance of the genus Akkermansia, which are both associated with efficient energy harvesting. The gut microbial diversity decreased in domestic yaks. The results of the shotgun-metagenomic sequencing showed that the wild yak harbored an increased abundance of microbial pathways that play crucial roles in digestion and growth of the host, whereas the domestic yak harbored an increased abundance of methane-metabolism-related pathways. Wild yaks had enriched amounts of REGs in energy and carbohydrate metabolism pathways, and possessed a significantly increased abundance of cellulases and endohemicellulases in the glycoside hydrolase family compared to domestic yaks. The concentrations of acetic, propionic, n-butyric, i-butyric, n-valeric, and i-valeric acid were highest in wild yaks. Our study displayed the domestic effect on the phenotype of composition, function in gut microbiota, and SCFAs associated with gut microbiota, which had a closely association with the growth performance of the livestock. These findings may enlighten the researchers to construct more links between economic characteristics and gut microbiota, and develop new commercial strains in livestock based on the biotechnology of gut microbiota.
关键词	Yak domestication 16S rDNA shotgun metagenomic sequencing fecal microbiota
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60829
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Fu, Haibo,Zhang, Liangzhi,Fan, Chao,et al. Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota[J]. FRONTIERS IN MICROBIOLOGY,2021,12.
APA	Fu, Haibo.,Zhang, Liangzhi.,Fan, Chao.,Liu, Chuanfa.,Li, Wenjing.,...&Zhang, Yanming.(2021).Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota.FRONTIERS IN MICROBIOLOGY,12.
MLA	Fu, Haibo,et al."Domestication Shapes the Community Structure and Functional Metagenomic Content of the Yak Fecal Microbiota".FRONTIERS IN MICROBIOLOGY 12(2021).