Synthesis of charged chitosan nanoparticles as functional biolubricant

NWIPB OpenIR

	Synthesis of charged chitosan nanoparticles as functional biolubricant
	Yang, Lumin; Zhao, Xiaoduo; Zhang, Jing; Ma, Shuanhong; Jiang, Lei; Wei, Qiangbing; Cai, Meirong; Zhou, Feng
	2021
发表期刊	COLLOIDS AND SURFACES B-BIOINTERFACES
卷号	206
摘要	Osteoarthritis has been a major disease in recent years, which is mainly related to the breakdown of the lubrication function of the cartilage sliding interface, along with the inflammation of the joint capsule. In this paper, one kind of novel biomimetic nanoparticles (NPs) lubricant, named CS-PS, is synthesized through chemically grafting hydrophilic sulfonic acid (SO3-) groups onto the surface of biocompatible and biodegradable chitosan (CS) NPs. Compared with control CS NPs, the as-synthesized CS-PS NPs exhibits excellent hydration and stability because of negatively charged surface zeta potential, along with extraordinary lubrication performance in water for realizing a super-low friction coefficient (COF) as similar to 0.01 at the sliding interface of PDMS elastomer-Ti6Al4V disk. Correspondingly, the CS-PS NPs can also be used as a drug carrier for aspirin, which presents very good drug loading and release behavior in PBS (pH = 7.4). MCS cells culture experiment proves that this kind of novel lubricant is nontoxic and biocompatible, for which may be expected to use as potential articular injective material for the treatment of osteoarthritis.
关键词	Surface modification Nanoparticles Osteoarthritis Water lubrication Drug release
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60700
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yang, Lumin,Zhao, Xiaoduo,Zhang, Jing,et al. Synthesis of charged chitosan nanoparticles as functional biolubricant[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2021,206.
APA	Yang, Lumin.,Zhao, Xiaoduo.,Zhang, Jing.,Ma, Shuanhong.,Jiang, Lei.,...&Zhou, Feng.(2021).Synthesis of charged chitosan nanoparticles as functional biolubricant.COLLOIDS AND SURFACES B-BIOINTERFACES,206.
MLA	Yang, Lumin,et al."Synthesis of charged chitosan nanoparticles as functional biolubricant".COLLOIDS AND SURFACES B-BIOINTERFACES 206(2021).