Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model

NWIPB OpenIR

	Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model
	Li, Maoru; Ma, Ji; Ahmad, Owais; Cao, Yi; Wang, Bing; He, Qiangqiang; Li, Jiajing; Yin, Hongli; Zhang, Yifan; He, Jiang; Shang, Jing
	2018
发表期刊	JOURNAL OF PHARMACOLOGICAL SCIENCES
卷号	138 期号:4
摘要	Nonalcoholic fatty liver disease (NAFLD) 1 is the most common chronic liver disease worldwide. Cichorium glandulosum Boiss. et Huet (CG) is a common traditional Uighur medicine, and it has been widely used as active therapy on various hepatic diseases. Recently, lipid-lowering effect has been revealed on CG. Polysaccharides are principal component of CG which could be the possible lipid-lowering compound in CG. In this study, extraction and purification of CG polysaccharides (CGP) was performed, and the lipid regulation effect of CGP was investigated on NAFLD zebrafish model. The results showed that CGP significantly decreased the levels of TC, TG, and decreased the mRNA expression of srebf-1, and fas, increased the expression of pparab. The findings suggest that the lipid-lowering effects of CGP mainly depend on facilitation of lipolysis (mainly beta-oxidation) or inhibition of lipogenesis. Furthermore, CGP could prevent and causes the regression of steatosis in NAFLD via its lipid metabolism regulation effect. (c) 2018 The Authors. Production and hosting by Elsevier B. V. on behalf of Japanese Pharmacological Society.
关键词	Cichorium glandulosum Boiss. et Huet Polysaccharides Non-alcoholic fatty liver disease Lipid-lowering Zebrafish
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59925
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Li, Maoru,Ma, Ji,Ahmad, Owais,et al. Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2018,138(4).
APA	Li, Maoru.,Ma, Ji.,Ahmad, Owais.,Cao, Yi.,Wang, Bing.,...&Shang, Jing.(2018).Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model.JOURNAL OF PHARMACOLOGICAL SCIENCES,138(4).
MLA	Li, Maoru,et al."Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model".JOURNAL OF PHARMACOLOGICAL SCIENCES 138.4(2018).