Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties

NWIPB OpenIR

	Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties
	Wang, Yongcui ; Fang, Jianwen ; Chen, Shilong
	2016-09-20
发表期刊	SCIENTIFIC REPORTS
摘要	Accurately predicting the response of a cancer patient to a therapeutic agent is a core goal of precision medicine. Existing approaches were mainly relied primarily on genomic alterations in cancer cells that have been treated with different drugs. Here we focus on predicting drug response based on integration of the heterogeneously pharmacogenomics data from both cell and drug sides. Through a systematical approach, named as PDRCC (Predict Drug Response in Cancer Cells), the cancer genomic alterations and compound chemical and therapeutic properties were incorporated to determine the chemotherapeutic response in cancer patients. Using the Cancer Cell Line Encyclopedia (CCLE) study as the benchmark dataset, all pharmacogenomics data exhibited their roles in inferring the relationships between cancer cells and drugs. When integrating both genomic resources and compound information, the prediction coverage was significantly increased. The validity of PDRCC was also supported by its effective in uncovering the unknown cell-drug associations with database and literature evidences. It set the stage for clinical testing of novel therapeutic strategies, such as the sensitive association between cancer cell 'A549_LUNG' and compound 'Topotecan'. In conclusion, PDRCC offers the possibility for faster, safer, and cheaper the development of novel anti-cancer therapeutics in the early-stage clinical trails.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/53261
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, Yongcui,Fang, Jianwen,Chen, Shilong. Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties[J]. SCIENTIFIC REPORTS,2016.
APA	Wang, Yongcui,Fang, Jianwen,&Chen, Shilong.(2016).Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties.SCIENTIFIC REPORTS.
MLA	Wang, Yongcui,et al."Inferences of drug responses in cancer cells from cancer genomic features and compound chemical and therapeutic properties".SCIENTIFIC REPORTS (2016).