Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification | |
| FU Yan-Yan; LI Xiao-Yan; SUN Zhi-Wei; QIN Xue-Qin; XIA Lian; SUO You-Rui; LI Yu-Lin; You JM(尤进茂) | |
| 2010 | |
| 发表期刊 | Chinese Journal of Analytical Chemistry
 |
| ISSN | 0253-3820 |
| 卷号 | 38期号:1页码:8-12 |
| 摘要 | Using three different derivatization methods to mark the amine compounds, we compared the difference of derivatization efficiency and gave the optimal method. 5-(2-Hydroxyethyl)benzoacridine reacts with coupling agent N,N′-carbonyldiimidazole (CDI) to form an activated amide intermediate 2-(benzoacridin)ethyl-imidazole-1-carboxylate (BAEIC). BAEIC, which is dual-sensitive probe, reacts preferably with amino compounds at 80 °C in the presence of 4-dimethylaminopyridine (DMAP) catalyst in N,N-dimethylformamide (DMF) solvent to give the corresponding sensitively fluorescent derivatives with an excitation maximum at 280 nm of λex and an emission maximum at 510 nm of λem. BAEIC-amine derivatives simultaneously exhibited high-ionization potential with percent ionization δ changing from 5.62% to 58.08% in aqueous acetonitrile and from 2.14% to 56.58% in aqueous methanol. Derivatives are not only sensitive to fluorescence but also to MS ionizable potential. The fluorescence detection limits are 0.12–0.59 ng mL？1 (at a signal-to-noise ratio of 3). The online Atmospheric Pressure Chemical Ionization Mass Spectrometry (APCI-MS) detection limits are 1.89–14.12 ng mL？1 (at a signal-to-noise ratio of 5). |
| 收录类别 | SCI |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/2014 |
| 专题 | 中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | FU Yan-Yan,LI Xiao-Yan,SUN Zhi-Wei,et al. Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification[J]. Chinese Journal of Analytical Chemistry,2010,38(1):8-12. |
| APA | FU Yan-Yan.,LI Xiao-Yan.,SUN Zhi-Wei.,QIN Xue-Qin.,XIA Lian.,...&尤进茂.(2010).Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification.Chinese Journal of Analytical Chemistry,38(1),8-12. |
| MLA | FU Yan-Yan,et al."Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification".Chinese Journal of Analytical Chemistry 38.1(2010):8-12. |
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