Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii

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	Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii
	Pan, Li ; Zhou, Ping ; Zhang, Xiaofeng ; Peng, Shulin ; Ding, Lisheng ; Qiu, Samuel X.
	2006-06-22
发表期刊	ORGANIC LETTERS
卷号	8 期号:13 页码:2775-2778
文章类型	Article
摘要	Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.; Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.
WOS标题词	Science & Technology ; Physical Sciences
学科领域	生物科学
收录类别	SCI ; IC
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000238284500030
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/1325
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China 2.Washington Univ, Sch Med, St Louis, MO 63110 USA 3.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Pan, Li,Zhou, Ping,Zhang, Xiaofeng,et al. Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii[J]. ORGANIC LETTERS,2006,8(13):2775-2778.
APA	Pan, Li,Zhou, Ping,Zhang, Xiaofeng,Peng, Shulin,Ding, Lisheng,&Qiu, Samuel X..(2006).Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS,8(13),2775-2778.
MLA	Pan, Li,et al."Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii".ORGANIC LETTERS 8.13(2006):2775-2778.